Alteration of several neurotransmitter systems has been implicated in the pathogenesis of schizophrenia since the 1950s parallel to the description of toxic psychosis and its mechanism action. First was related to serotonin dysfunction in this disease produced following LSD psychosis.
This hypothesis was in second place to discover the mechanism of action of antipsychotic drugs with the production of psychotic symptoms by dopamine agonists, which led to the dopaminergic theory formulated in the early 70s. This hypothesis was to explain both the positive symptoms as part of the cognitive deficits of the disease, but does not respond to all the symptoms that can occur in the evolution of schizophrenic patients. Hence, new theories emerged later as the GABAergic and glutamatergic (related to the model of phencyclidine psychosis.)
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